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KMID : 0984720060380030146
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Infection and Chemotherapy
2006 Volume.38 No. 3 p.146 ~ p.153
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Evaluation of a New Diagnostic Test for Invasive Fungal Infections Using Prophenoloxydase System to Measure (1-->3)-beta-D-glucan Concentration
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Lee Ki-Deok
Yoon Jong-Won
Bae Jung-Shik
Auh Joong-Hyuck
Lee Bok-Luel
Kim Eu-Suk
Park Wan-Beom
Kim Hong-Bin
Kim Nam-Joong
Oh Myoung-Don
Choe Kang-Won
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Abstract
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Background: Prognosis of invasive fungal infection is supposed to be better when diagnosed earlier. (1-->3)-beta-D-glucan (BDG) test is considered useful in early diagnosis of invasive fungal infections among high-risk patients. A new diagnostic test using prophenoloxydase system to measure BDG level is developed. A study was performed to evaluate clinical usefulness of this new diagnostic test.
Materials & Methods: 15 patients of confirmed invasive fungal infections and 38 healthy normal volunteers were enrolled. Plasma or serum BDG concentrations were measured using prophenoloxydase system. Assays for intra-run variability and inter-run variability were performed. A cut-off value was determined and sensitivity and specificity of the test were evaluated.
Results: A cut-off value of 94.90 pg/mL was determined. Sensitivity and specificity of the test were 86.7% and 52.6%, respectively. Statistical analyses of inter-run variability and intra-run variability revealed the test is reliable (P< or =0.001).
Conclusion: BDG test using prophenoloxydase system is a sensitive and reliable test in non- invasive detection of invasive fungal infection.
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KEYWORD
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Invasive fungal infection, Non-invasive diagnosis, (1-->3)-beta-D-glucan, Prophenoloxydase system
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